| 產(chǎn)品編號 | bs-0591R |
| 英文名稱 | TNFRSF10A Rabbit pAb |
| 中文名稱 | 死亡受體4抗體 |
| 別 名 | APO2; CD261; DR4; TRAILR-1; TRAILR1; TR10A_HUMAN; TNFRSF10A; Death receptor 4; TNF-related apoptosis-inducing ligand receptor 1 (TRAIL receptor 1 | TRAIL-R1); |
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Specific References (2) | bs-0591R has been referenced in 2 publications.
[IF=7.129] Furui Han. et al. In vivo and in vitro study on hepatotoxicity of Tris-(2, 3-dibromopropyl) isocyanurate exposure via mitochondrial and death receptor pathway. ECOTOX ENVIRON SAFE. 2022 Nov;246:114186 WB ; Rat, Human.
[IF=3.752] Zhao Zhang. et al. Effect of matrine in MAC-T cells and their transcriptome analysis: A basic study. PLOS ONE. 2023 Jan;18(1):e0280905 WB ; Bovine.
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| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 | WB=1:200-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 50 kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | Recombinant human TNFRSF10A protein |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008] Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Subunit: Can interact with TRADD and RIPK1. Interacts with ARAP1. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells. Similarity: Contains 1 death domain. Contains 3 TNFR-Cys repeats. SWISS: O00220 Gene ID: 8797 Database links: Entrez Gene: 8797 Human SwissProt: O00220 Human |
| 產(chǎn)品圖片 |
Sample:
Lane 1: Human Jurkat cell lysates
Lane 2: Human A549 cell lysates
Lane 3: Human HUVEC cell lysates
Lane 4: Human HeLa cell lysates
Primary: Anti-TNFRSF10A (bs-0591R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 50 kDa
Observed band size: 60 kDa
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