| 產(chǎn)品編號 | bs-0417R |
| 英文名稱 | Rabbit Anti-TIMP-3 antibody |
| 中文名稱 | 金屬蛋白酶組織抑制因子-3抗體 |
| 別 名 | HSMRK222; K222; K222TA2; Metalloproteinase inhibitor 3; TIMP3; TIMP 3; MIG 5 protein; MIG5 protein; Protein MIG 5; SFD; Sorsby fundus dystrophy pseudoinflammatory; TIMP metallopeptidase inhibitor 3; TIMP3; Tissue Inhibitor of Metalloproteinase 3; Tissue inhibitor of metalloproteinases3; TIMP3_HUMAN. |
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Specific References (7) | bs-0417R has been referenced in 7 publications.
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| 研究領(lǐng)域 | 腫瘤 心血管 細(xì)胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 合成與降解 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human (predicted: Mouse,Rat,Rabbit,Pig,Cow,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 21kDa |
| 細(xì)胞定位 | 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TIMP-3: 151-211/211 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]. Subunit: Interacts with EFEMP1. Subcellular Location: Secreted, extracellular space, extracellular matrix. Similarity: Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain. SWISS: P35625 Gene ID: 7078 Database links: Entrez Gene: 7078 Human Entrez Gene: 21859 Mouse Omim: 188826 Human SwissProt: P35625 Human SwissProt: P39876 Mouse Unigene: 644633 Human 合成與降解（Synthesis and Degradation） 近年來，國內(nèi)外科研人員對TIMP-3的抗腫瘤作用日益被重視，學(xué)者認(rèn)為：TIMP-3具有強(qiáng)烈促凋亡、抑制血管生成、抗腫瘤浸潤作用，TIMP-3與TIMP-1、2且相互間有明顯協(xié)同抗腫瘤作用 |
| 產(chǎn)品圖片 |
Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-TIMP-3 Polyclonal Antibody, Unconjugated(bs-0417R) 1:100, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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