| 產(chǎn)品編號(hào) | bs-1932R |
| 英文名稱 | Vitronectin Rabbit pAb |
| 中文名稱 | 玻璃粘連蛋白抗體 |
| 別 名 | Complement S Protein; Epibolin; S Protein; Serum Spreading Factor; V75; Vitronectin V10 subunit; VN; VNT; VTN; S-protein; Serum-spreading factor; V75; Vitronectin V10 subunit; VTNC_HUMAN. |
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Specific References (4) | bs-1932R has been referenced in 4 publications.
[IF=18.962] Kui Chen. et al. Reversing the pathological microenvironment by radiocatalytic sensitizer for local orthotopic osteosarcoma radiotherapy enhancement. NANO TODAY. 2023 Feb;48:101739 IHC ; Mouse.
[IF=7.6] Wang, Yang, et al. "Induced apoptosis of osteoblasts proliferating on polyhydroxyalkanoates." Biomaterials (2013). Rat.
[IF=3.382] Meng GL et al. Effect of zinc substitution in hydroxyapatite
coating on osteoblast and osteoclast
differentiation under osteoblast/
osteoclast co-culture. Regenerative Biomaterials, 2019, 1–11. IF ; Mouse.
[IF=1.889] Chao Gong. et al. Over-expression of vitronectin correlates with impaired survival in gastric cancers. Medicine. 2021 Aug 6; 100(31): e26766 IHC ; Human.
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| 研究領(lǐng)域 | 心血管 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Mouse (predicted: Human,Rat,Cow,Dog) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 9/52 kDa |
| 檢測分子量 | |
| 細(xì)胞定位 | 細(xì)胞外基質(zhì) 分泌型蛋白 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Vitronectin: 381-478/478 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Vitronectin (also known as serum spreading factor, S protein of complement or epibolin) is one of the major multifunctional cell adhesive glycoproteins in mammalian plasma and serum. It is a monomeric acidic glycoprotein detected as a mixture of 75 kD and 65 kD polypeptides. Vitronectin binds to heparin, collagen, streptococci and variety of cultured cells. It also acts as an inhibitor of the complement cascade by binding to the C5b9 complex. Vitronectin promotes cell adhesion and spreading by binding through its cell attachment tripeptide Arg-Gly-Asp (RG-D), activity which is mediated by several different integrin receptors. Apart from the significance for identifying the molecule in the above situations, it also plays an important role in events such as embryonal development, deposition of vitronectin in a number of fibrotic disease states, carcinomas and metastases. Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity). Subunit: Monomer. Interacts with SERPINE1/PAI1 (By similarity). Subcellular Location: Secreted, extracellular space. Tissue Specificity: Plasma. Post-translational modifications: Sulfated on 2 tyrosine residues (By similarity). N- and O-glycosylated (By similarity). It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both. Similarity: Contains 4 hemopexin-like domains. Contains 1 SMB (somatomedin-B) domain. SWISS: P04004 Gene ID: 7448 Database links: Entrez Gene: 7448 Human Entrez Gene: 22370 Mouse Omim: 193190 Human SwissProt: P04004 Human SwissProt: P29788 Mouse Unigene: 2257 Human Unigene: 3667 Mouse |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Vitronectin) Polyclonal Antibody, Unconjugated (bs-1932R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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