| 產(chǎn)品編號(hào) | bs-8267R |
| 英文名稱 | Rabbit Anti-GIMAP1 antibody |
| 中文名稱 | GTP酶IMAP家族成員1抗體 |
| 別 名 | GIMA1_HUMAN; GIMAP1; GTPase IMAP family member 1; hIMAP1; Immunity-associated protein 1. |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) G蛋白偶聯(lián)受體 G蛋白信號(hào) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Rat (predicted: Human,Mouse,Rabbit,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 34kDa |
| 細(xì)胞定位 | 細(xì)胞漿 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GIMAP1: 31-130/306 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
The GTPase of the immunity-associated protein (GIMAP) family of proteins include seven members that are expressed by genes residing on human chromosome 7. GIMAP proteins have been implicated in the regulation of lymphomyeloid cell survival. GIMAP1 (GTPase, IMAP family member 1), also known as IMAP1 (immunity-associated protein 1), HIMAP1 or IMAP38, is a 306 amino acid single-pass type IV membrane protein of the endoplasmic reticulum (ER) belonging to the GIMAP family. Encoded by a gene located on human chromosome 7, GIMAP1 is expressed primarily in spleen with lower levels found in lymph node. Chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome and has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. Function: May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity). Subcellular Location: Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Golgi apparatus membrane (By similarity). Tissue Specificity: Predominantly expressed in the spleen and to a lesser extent in the lymph nodes. Similarity: Belongs to the IAN GTP-binding protein family. SWISS: Q8WWP7 Gene ID: 170575 Database links: Entrez Gene: 170575 Human Omim: 608084 Human SwissProt: Q8WWP7 Human Unigene: 647087 Human |
| 產(chǎn)品圖片 |
Paraformaldehyde-fixed, paraffin embedded (rat lymphoid); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GIMAP1) Polyclonal Antibody, Unconjugated (bs-8267R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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