| 產(chǎn)品編號 | bs-14489R |
| 英文名稱 | EDEM1 Rabbit pAb |
| 中文名稱 | EDEM1蛋白抗體 |
| 別 名 | EDEM; A130059K23Rik; mKIAA0212; EDEM1_HUMAN; EDEM1; KIAA0212; EDEM1_MOUSE; |
| 研究領(lǐng)域 | 細胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 74 kDa |
| 細胞定位 | 細胞漿 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human ECT2 around the phosphorylation site of Thr790: 551-657/657 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Proteins expressed in the endoplasmic reticulum (ER) are subjected to a tight quality control. Terminally misfolded proteins in the endoplasmic reticulum (ER) are retrotranslocated to the cytoplasm and degraded by proteasomes through a mechanism known as ER-associated degradation (ERAD). EDEM (ER degradation-enhancing alpha-mannosidase-like) protein is a type II membrane protein that localizes to the ER and is directly involved in ERAD. EDEM targets misfolded glycoproteins for degradation in an N-glycan-dependent manner and extracts misfolded glycoproteins from the calnexin cycle. The human EDEM gene maps to chromosome 3p. Function: EDEM1 is directly involved in ER associated degradation (ERAD), and targets misfolded glycoproteins for degradation in an N glycan dependent manner. It lacks mannosidase activity. EDEM1 belongs to the glycosyl hydrolase 47 family. Subunit: Interacts with DNAJC10 (By similarity). Interacts with DERL2 and DERL3. Binds to SEL1L. Subcellular Location: Endoplasmic reticulum membrane. Similarity: Belongs to the glycosyl hydrolase 47 family. SWISS: Q92611 Gene ID: 9695 Database links: Entrez Gene: 9695 Human Entrez Gene: 192193 Mouse SwissProt: Q92611 Human SwissProt: Q925U4 Mouse
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