| 產(chǎn)品編號 | bs-14741R |
| 英文名稱 | FAM162A Rabbit pAb |
| 中文名稱 | FAM162A蛋白抗體 |
| 別 名 | C3orf28; E2IG5; HGTD-P; F162A_HUMAN; FAM162A; E2-induced gene 5 protein; Growth and transformation-dependent protein (HGTD-P); |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 克 隆 號 | |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Pig,Horse) |
| 產(chǎn)品應(yīng)用 | ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 17 kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FAM162A: 1-100/154 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
HGTD-P (human growth and transformation-dependent protein), also known as E2IG5 or FAM162A, is a 154 amino acid single-pass membrane protein belonging to the UPF0389 family. Considered a proapoptotic protein, HGTD-P is an effector of cell death induced by hypoxia-ischemia (HI) and is therefore considered a potential target in treating HI-induced brain damage. HGTD-P localizes to the mitochondria and, when overexpressed, induces the mitochondrial permeability transition by interacting with voltage dependent anion channels. HGTD-P facilitates apoptotic cell death via the mitochondrial apoptotic cascades, including permeability transition, cytochrome c release and caspase 9 activation. HGTD-P is regulated and activated by HIF-1?through a hypoxia-responsive element on the HGTD-P promoter region. Subcellular Location: Membrane. Similarity: Belongs to the UPF0389 family. SWISS: Q96A26 Gene ID: 26355 Database links: Entrez Gene: 26355 Human Omim: 608017 Human SwissProt: Q96A26 Human Unigene: 584881 Human |
