| 產(chǎn)品編號(hào) | bs-18349R |
| 英文名稱 | Rabbit Anti-LPHN2 antibody |
| 中文名稱 | 蛛毒素受體2抗體 |
| 別 名 | Calcium-independent alpha-latrotoxin receptor 2; CIRL-2; CL2; KIAA0786; Latrophilin 1; Latrophilin 2; Latrophilin homolog 1; latrophilin homolog 2; LEC1; Lectomedin-1; LPH2; LPHH1; LPHN2_HUMAN. |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號(hào) |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,Horse) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 160kDa |
| 細(xì)胞定位 | 細(xì)胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LPHN2: 531-630/1459 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined. [provided by RefSeq, Jul 2008] Function: Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor propably implicated in the regulation of exocytosis. Subunit: Forms a heterodimer, consisting of a large extracellular region (p120) non-covalently linked to a seven-transmembrane moiety (p85) Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others. Post-translational modifications: Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain. Contains 1 olfactomedin-like domain. Contains 1 SUEL-type lectin domain. SWISS: O95490 Gene ID: 23266 Database links: Entrez Gene: 100052932 Horse Entrez Gene: 23266 Human Entrez Gene: 100405265 Marmoset (common) Entrez Gene: 99633 Mouse Entrez Gene: 100013683 Opossum Entrez Gene: 100343149 Rabbit Entrez Gene: 100551470 Turkey Omim: 607018 Human SwissProt: O95490 Human SwissProt: Q8JZZ7 Mouse Unigene: 24212 Human Unigene: 9776 Mouse Unigene: 12089 Rat |
