產(chǎn)品編號 | bs-43749P |
英文名稱 | Recombinant mouse SIGLEC1 protein, C-His (HEK293) |
中文名稱 | 重組小鼠CD169蛋白 |
別 名 | CD 169; CD-169; dJ1009E24.1; DKFZp667F058; FLJ00051; FLJ00055; FLJ00073; FLJ00411; FLJ32150; Sialic acid binding Ig like lectin 1; Sialic acid binding immunoglobulin like lectin 1; Siglec 1; SN; sialoadhesin; SN_HUMAN; |
克 隆 號 | |
理論分子量 | 176.7 kDa |
檢測分子量 | |
性 狀 | Liquid |
濃 度 | >1mg/ml |
純 度 | >90% as determined by SDS-PAGE |
緩 沖 液 | PBS (pH=7.4) |
保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles |
注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
產(chǎn)品介紹 |
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]. SWISS: Q62230 Gene ID: 20612 CD169,又稱sialoadhesin(Sn)或Siglee-1,這是一種200kDa的I型跨膜糖蛋白,由炎性巨噬細(xì)胞特異性表達(dá),在細(xì)胞-細(xì)胞或細(xì)胞-基質(zhì)的相互作用中發(fā)揮主要作用。可識別乳癌細(xì)胞的MUC1(CD227)和T細(xì)胞的CD43。CD169在脾、淋巴結(jié)、骨髓的基質(zhì)巨噬細(xì)胞上表達(dá)最強,在肝、腸、肺的長駐巨噬細(xì)胞上中等表達(dá),慢性炎組織的巨噬細(xì)胞,例如類風(fēng)濕性滑膜、動脈粥樣硬化性斑塊,也強烈表達(dá)CD169。 |
產(chǎn)品圖片 | |