| 產(chǎn)品編號(hào) | bs-0378R-BF488 |
| 英文名稱 | Rabbit Anti-Runx3/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的Runx3抗體 |
| 別 名 | This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Human, (predicted: Mouse, Rat, Chicken, Dog, Cow, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 44kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Runx3 (160-205aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: RUNX3 binds to the core site of murine Leukemia virus, the core sequences in the enhancer of the polyomavirus, and also to the enhancers of the T-cell receptor genes. May be involved in the control of cellular proliferation and/or differentiation (By similarity). Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain.DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1, Subcellular location in Nucleus. Function: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. Subunit: Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1. The tyrosine phosphorylated form (via runt domain) interacts with SRC (via protein kinase domain). Interacts with FYN and LCK. Subcellular Location: Nucleus. Cytoplasm. Note=The tyrosine phosphorylated form localizes to the cytoplasm. Post-translational modifications: Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN. Similarity: Contains 1 Runt domain. Database links: Entrez Gene: 864 Human Omim: 600210 Human SwissProt: Q13761 Human Unigene: 170019 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 新型抑癌基因/一種新發(fā)現(xiàn)的抑癌基因。經(jīng)研究發(fā)現(xiàn),在人類胃癌細(xì)胞系和胃癌組織中普遍存在Runx3基因表達(dá)的缺失或下調(diào),該蛋白與胃癌的發(fā)生、發(fā)展密切相關(guān)。 RUNX3基因被認(rèn)為是一種新發(fā)現(xiàn)的抑癌基因,對(duì)胃癌細(xì)胞的生長(zhǎng)有明顯的抑制作用在胃黏膜上皮細(xì)胞調(diào)控、對(duì)脊神經(jīng)節(jié)的神經(jīng)發(fā)育和T細(xì)胞分化中都發(fā)揮重要作用。 隨著研究的不斷深入，Runx3蛋白有望成為胃癌診斷的一個(gè)新型生物學(xué)標(biāo)志物和基因治療靶點(diǎn)。 |
