| 產(chǎn)品編號(hào) | bs-1132R-APC |
| 英文名稱 | Rabbit Anti-Somatostatin 28/APC Conjugated antibody |
| 中文名稱 | APC標(biāo)記的生長(zhǎng)抑素抗體 |
| 別 名 | GRIH; Growth hormone release inhibiting factor; SMS_HUMAN; SMST; SST; Somatostatin 14; Somatostatin14; Somatostatin-14; somatostatin SS14; Somatostatin 28; Somatostatin28; Somatostatin-28; somatostatin SS28. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 神經(jīng)生物學(xué) 生長(zhǎng)因子和激素 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, Rat, (predicted: Human, Chicken, Pig, Cow, Sheep, ) |
| 產(chǎn)品應(yīng)用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 13kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Somatostatin 28 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]. Function: Somatostatin inhibits the release of somatotropin. Subcellular Location: Secreted. Similarity: Belongs to the somatostatin family. Database links: Entrez Gene: 396279 Chicken Entrez Gene: 6750 Human Entrez Gene: 20604 Mouse Omim: 182450 Human SwissProt: P33094 Chicken SwissProt: P61278 Human SwissProt: P60041 Mouse Unigene: 12409 Human Unigene: 34418 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 生長(zhǎng)抑素是胰島D細(xì)胞的一種多肽激素，主要用于胰島細(xì)胞的功能性分類和消化道粘膜中內(nèi)分泌細(xì)胞及腫瘤的研究。 生長(zhǎng)抑素在體內(nèi)分布廣泛。在神經(jīng)系統(tǒng)中，廣泛存在于中樞和外周神經(jīng)系統(tǒng)，在腦內(nèi)以下丘腦正中隆起的濃度為最高。在新皮層，邊緣系統(tǒng)下杏仁核，海馬等部位也廣泛存在，以皮層含量最高。在脊髓后根和三叉神經(jīng)神經(jīng)節(jié)內(nèi)的一級(jí)神經(jīng)元中，亦含生長(zhǎng)抑素的免疫反應(yīng)性物質(zhì)。生長(zhǎng)抑素廣泛存在于胃腸道粘膜的“D”細(xì)胞，以胃竇和胃體最高，在腸內(nèi)越往下含量越低?！癉”細(xì)胞有長(zhǎng)的胞漿突起，在幽門腺區(qū)止于G細(xì)胞和“嗜鉻細(xì)胞”，在泌酸腺區(qū)止于壁細(xì)胞和其他上皮細(xì)胞。生長(zhǎng)抑素通過(guò)旁分泌機(jī)制由突起釋放到G細(xì)胞和壁細(xì)胞膜上，抑制胃泌素和HCI分泌，在胰腺內(nèi)，生長(zhǎng)抑素由胰島“D”細(xì)胞分泌，通過(guò)血液循環(huán)對(duì)胰島及消化道起作用，作為旁分泌調(diào)節(jié)胰島功能。 生長(zhǎng)抑素的生理作用為：抑制垂體生長(zhǎng)激素、促甲狀腺激素、促腎上腺皮質(zhì)激素和催乳類的釋放，也抑制各種胃腸激素的釋放，抑制胃泌素、促胰液素、膽囊收縮素、胃動(dòng)素、胰多肽、胰高血糖素、腸高血糖素等的釋放。同時(shí)也抑制胃酸、胃蛋白酶、胰蛋白酶及唾液淀粉酶的分泌。 |
