| 產(chǎn)品編號(hào) | bs-1282R-BF647 |
| 英文名稱 | Rabbit Anti-ASPP1/BF647 Conjugated antibody |
| 中文名稱 | BF647標(biāo)記的p53凋亡刺激蛋白1抗體 |
| 別 名 | p53BP2 like; p85; PPP1R13B; apoptosis stimulating protein of P53 1; Apoptosis-stimulating of p53 protein 2; Tumor suppressor p53-binding protein 2; p53-binding protein 2; p53BP2; 53BP2; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買 大包裝/詢價(jià) |
| 說(shuō) 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞凋亡 |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, ) |
| 產(chǎn)品應(yīng)用 | IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 120kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human ASPP1 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: iASPP (inhibitor of apoptosis stimulating protein of p53, RelA-associated inhibitor (RAI), NFKap B-interacting protein 1, protein phosphatase 1 regulatory subunit 13-like, PPP1R13L) is the third member of the ASPP family of proteins. Unlike ASPP1 and ASPP2, which interact with p53 and enhance its ability to induce apoptosis, iASPP inhibits apoptosis induced by p53 overexpression. iASPP has been identified in a yeast-two hybrid screen as an interacting protein of the p65 subunit of NFKap B (RelA),3 interacts with NFKap B in vivo, and acts as an efficient inhibitor of HIV-1 gene expression in which both NFKap b and Sp1 play major roles. iASPP expression is upregulated in human breast carcinomas expressing wild-type p53, and gene overexpression may play an important role in the leukemogenesis and/or progression of acute leukemia. Alternate Names: apoptosis stimulating protein of P53 1; Apoptosis-stimulating of p53 protein 2; Tumor suppressor p53-binding protein 2; p53-binding protein 2; p53BP2; 53BP2; Bcl2-binding protein; Bbp; Renal carcinoma antigen NY-REN-51. Function: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Subunit: Interacts with TP53. Subcellular Location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Some fraction is nuclear. Tissue Specificity: Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Similarity: Belongs to the ASPP family. Contains 2 ANK repeats. Contains 1 SH3 domain. Database links: Entrez Gene: 23368 Human Entrez Gene: 21981 Mouse Omim: 606455 Human SwissProt: Q96KQ4 Human SwissProt: Q62415 Mouse Unigene: 709297 Human Unigene: 313076 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. p53凋亡刺激蛋白(apoptosis stimulating protein of p53，ASPP)家族是近年來(lái)發(fā)現(xiàn)的一個(gè)新蛋白家族，它包括3個(gè)成員：ASPP1、ASPP2和其中ASPP1和ASPP2能夠與p53蛋白結(jié)合增強(qiáng)該蛋白的促進(jìn)細(xì)胞凋亡的功能，發(fā)揮抑制腫瘤的作用；而iASPP與ASPP1和ASPP2的功能截然相反，它能夠和ASPP1或ASPP2競(jìng)爭(zhēng)性地與p53結(jié)合，抑制ASPP1或ASPP2的促進(jìn)凋亡作用，具有癌基因的功能。三者的結(jié)構(gòu)相似，但功能卻完全不同，通過研究三者的關(guān)系、促進(jìn)腫瘤細(xì)胞內(nèi)ASPP1或ASPP2的高表達(dá)以及抑制iASPP的表達(dá)有可能促進(jìn)腫瘤細(xì)胞的凋亡，成為腫瘤治療的新靶點(diǎn). |
