| 產(chǎn)品編號 | bs-15385R-BF488 |
| 英文名稱 | Rabbit Anti-GPR161/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的G蛋白偶聯(lián)受體GPR161蛋白抗體 |
| 別 名 | FLJ33952; G-protein coupled receptor 161; G-protein coupled receptor RE2; GP161; GPR161; RE2; GP161_HUMAN. |
| 規(guī)格價(jià)格 | 100ul/2980元 購買 大包裝/詢價(jià) |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 59kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human GPR161 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G-protein coupled receptors translate extracellular signals into intracellular signals (G-protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR161 (G protein-coupled receptor 161), also known as RE2, is a 529 amino acid protein that belongs to the G-protein coupled receptor family. Localized to the cell membrane, GPR161 is a multi-pass membrane protein that functions as an orphan receptor, relaying extracellular signals to the intracellular environment. Two isoforms of GPR161 exist due to alternative splicing events. Function: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). Subcellular Location: Cell projection, cilium membrane; Multi-pass membrane protein (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). Note=Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity). Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 23432 Human Entrez Gene: 240888 Mouse SwissProt: Q8N6U8 Human SwissProt: B2RPY5 Mouse Unigene: 271809 Human Unigene: 329929 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
